To study the effects of blueberry anthocyanin on organ tissue antioxidant activity in experimental diabetic mice. The instreptozotocin-induced diabetic mice were divided into different groups. Diabetic mice were administered for 4 weeks, Malondialdehyde content, the activity of superoxide dismutase and glutathione peroxides, total antioxidant capacity, inhibiting ability of hydroxyl radicals on organ tissue were determined. The experimental data showed that model with blueberry anthocyanin group compared with model control, the content of Malondialdehyde were significantly reduced (P<0.05) while glutathione peroxidase，superoxide dismutase and total antioxidant capacity, inhibiting hydroxyl free radical ability increased markedly in the tissue of all organ (P<0.05). It shows that Blueberry anthocyanin can enhance the cell tissue antioxidant activity.