The orthogonal array design methods were applied to analyze the influence of H₂O₂ volume/HNO₃ volume/microwave digestion time three factors and their interaction on the extraction of Cd，select an optimized progress to extract Cd from shrimps. The experimental results showed that when H₂O₂ volume was 1.0 mL, HNO₃ volume is 5.0 mL, microwave digestion time was 13 minutes and 46 seconds, under these conditions，the contents of Cd reached 0.497 mg/kg. Determination of GBW10050 (big shrimps) showed that contents of Cd have the same results with standards values. Method limits of detection were obtained within the range of 0.01 μg /kg，the precision for this method was better than 5%. It allowed simple, rapid, sensitive and accurate determination of Cd in shrimps.