According to monitoring data of rice of Guangdong from 2012 to 2014, assessment on exposure of lead, cadmium in Guangdong residents was made by the method of China Total Diet Study. The contents of lead, cadmium in the rice of Guangdong were measured through the food safety risk monitoring from 2012 to 2014. The margin of exposure (MOE) of lead, estimated monthly intake (EMI) of cadmium were worked out as evaluation criteria. The over limit rate of lead, cadmiumin in Guangdong Province rice were 0.11%, 622% respectively. In addition to parts of cadmium in rice exceed the standard rate is higher than (up to 16.2%～22.4%), the majority of the remaining area of lead, cadmium content in rice is in low level. The MOE of lead of Guangdong residents was estimated to be 10.6～42.5. The EMI of cadmium ranged from 9.0 to 27.3 μg/kg·BW, which were 36%～109% of provisional tolerable monthly intake (PTMI). The contents of lead, cadmium and the intake in the crowd of Guangdong Province rice intake in the overall are in the safety level. But rice cadmium pollution in some parts of the area is not optimistic and has regional differences; Some potential risk population of edible rice cadmium exposure, especially in the area of northern Guangdong is very.