GM food is an important achievement in the development of biotechnology, and it has two sides as any other achievements. Taking into account the special nature of GM food, it needs to make effective legal regulation to regulate the impossible problems. Europe, Japan and other developed countries establish experimental and listing approval system, a isolation system and labeling system specifically. The US also sets up legal principle of non discrimination for supervision of GM food. Combined with the present situation of legal regulation on GM food in China, several steps should be taken, for adopting formal legislation, enacting specific workable implementation regulations and establishing industry access system, strengthening law enforcement, and adhering to the principles of law into a non discriminatory and so on, to ensure the legal regulation of GM food to regulate the special risk of it, and do not hinder the normal development of the GM industry.